Gennady Gorin
中文導讀
Gennady Gorin(LiorPachter lab)做的是 velocity 的 biophysics——用 chemical master equation 嚴格描述 transcription,並特別關注 normalization 對 velocity 的影響。他的 PhD centerpiece 發在 Nat Methods(2026)。他代表 velocity-skepticism 裡「修 biophysics / 正視 normalization」這一路,跟 Pachter 的 public critique、JianhuaXing 的 dynamical-systems critique 三角呼應。
Who
Researcher in the LiorPachter lab; biophysics of RNA velocity — chemical master equation (CME) models of transcription and the effect of normalization on velocity estimates. PhD centerpiece published in Nat Methods (2026).
Key work
- Monod (monod-gorin; Gorin, Chari, Carilli, Vastola, Pachter; Nat Methods) — fits stochastic CME transcription models to nascent+mature counts, minimizing distortive normalization; his PhD centerpiece.
- “RNA velocity unraveled” (PLoS Comput Biol 2022) and the Caltech thesis “Stochastic foundations for single-cell RNA sequencing” — the critique groundwork.
Position
The constructive-biophysics pole of velocity-skepticism: rather than dismiss velocity, argue that much apparent signal is technical (normalization, sampling) and that biophysically rigorous CME-based models are required (velocity-discourse-2025-2026). Aligns on the identifiability gap with JianhuaXing’s dynamical-systems-formulation and the wiki’s physical-time-grounding lens.
Related
monod-gorin · velocity-skepticism · LiorPachter · JianhuaXing · physical-time-grounding · splicing-kinetics-ode · RNA velocity · velocity-discourse-2025-2026