RNA Velocity Wiki

Hu Yizhou (胡益洲)

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tagsperson, rna-velocity-2018, karolinska, linnarsson

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Hu Yizhou (胡益洲)

Not to be confused with Zhiyuan Hu, the RegVelo co-first author — a different person. Hu Yizhou (胡益洲) contributed to the 2018 original RNA velocity preprocessing; he is not an author of RegVelo.

中文導讀

胡益洲(Hu Yizhou,現於 Karolinska)是 2018 第一篇 RNA velocity(RNA velocity, La Manno et al., Nature)preprocessing 的參與者——2018 春天在 Sten Linnarsson lab 跟 Gioele La Manno 一起改 STRT-seq 的 velocity 前處理。在 2026-06 的討論裡,他是順著 JianhuaXing 的討論做 follow-up(回顧 2018 起源、稱讚 Xing 的 slides、承認 Xing–Weissman 的 critique 抓到核心問題),不是在為 RegVelo 辯解——他本來就不是 RegVelo 作者。立場務實: 承認 velocity 在 transcriptome 層面有假設缺陷、現在更靠 lineage tracing,但仍把 velocity 當有 價值的 auxiliary evidence(見 xing-hu-regvelo-debate)。

Who

A contributor to the 2018 origin RNA velocity paper’s preprocessing. In spring 2018 he reworked the velocity preprocessing with Gioele La Manno (before La Manno’s PhD defence) for Sten Linnarsson’s early STRT-seq data, anticipating reviewer questions — though the final paper did not require STRT-seq. Now at Karolinska. He is not an author of RegVelo; the similarly-named RegVelo co-first author Zhiyuan Hu is a different person.

Role in the 2026-06 correspondence

A collegial follow-up to JianhuaXing’s discussion, not a defence of any method (xing-hu-regvelo-debate):

  • Recounts the 2018 origin: idea→submission in roughly half a year (Peter Kharchenko’s group pushing fast); velocity’s transcriptome-level assumptions had real flaws only flexibly worked around at the time.
  • The Linnarsson division largely moved on from velocity (technical barriers, shifting directions); later groups refined the model, some for UX reasons.
  • Agrees the JianhuaXing–Weissman critique caught some core problems, and praises Xing’s theory slides and long-arc program (theory → live-cell imaging → interpretable large-data models).
  • Eight–nine years on, relies increasingly on lineage tracing for proof, but still keeps velocity as valuable auxiliary evidence (a pragmatic, non-polemic stance).

Relation to others

RNA velocity · velocyto-2018 · velocyto · JianhuaXing · xing-hu-regvelo-debate · physical-time-grounding · FlowVelo

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