Felix Naef

中文導讀

Felix Naef 是 EPFL 的 computational systems biology PI,長期做 circadian rhythms 與 cell cycle 的定量動力學——本來就是「physical-time biology」這條線的人。他是 VeloCycle (velocycle-2024)的共同通訊作者(與 GioeleLaManno),把他在 periodic biological clocks 的 statistical-inference 專長帶進 RNA velocity,正好對應本 wiki 最在意的 metric-time grounding。

Who they are

Computational systems-biology PI at EPFL, known for quantitative modeling of circadian rhythms and the cell cycle — periodic biological clocks studied in real (physical) time. Co-corresponding author of velocycle-2024 / VeloCycle with GioeleLaManno; his expertise in statistical inference on periodic processes underlies VeloCycle’s treatment of the cell cycle as a 1D periodic manifold with phase-dependent angular speed.

Why they matter to this wiki

VeloCycle’s reach into metric, experimentally validated cell-cycle time is partly a systems- biology-of-clocks contribution: framing velocity inference around a known-period process and anchoring the rate scale with measured half-lives is exactly the move a circadian/cell-cycle modeler brings. He represents the periodic-clock route to physical-time-grounding — complementary to the metabolic-labeling route (dynamo).

Connections

• velocycle-2024 / VeloCycle — co-corresponding author.
• GioeleLaManno — co-corresponding author; the RNA-velocity-origin side of the collaboration.
• physical-time-grounding — the periodic-clock route to metric time.
• FlowVelo — periodic-process modeling as a template for grounding physical time.